markovMSM - Methods for Checking the Markov Condition in Multi-State Survival Data

The inference in multi-state models is traditionally performed under a Markov assumption that claims that past and future of the process are independent given the present state. In this package, we consider tests of the Markov assumption that are applicable to general multi-state models. Three approaches using existing methodology are considered: a simple method based on including covariates depending on the history in Cox models for the transition intensities; methods based on measuring the discrepancy of the non-Markov estimators of the transition probabilities to the Markov Aalen-Johansen estimators; and, finally, methods that were developed by considering summaries from families of log-rank statistics where patients are grouped by the state occupied of the process at a particular time point (see Soutinho G, Meira-Machado L (2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H (2020) <doi:10.1093/biostatistics/kxaa030>).

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2.95 score 18 scripts 267 downloads

survivalREC - Nonparametric Estimation of the Distribution of Gap Times for Recurrent Events

Provides estimates for the bivariate and trivariate distribution functions and bivariate and trivariate survival functions for censored gap times. Two approaches, using existing methodologies, are considered: (i) the Lin's estimator, which is based on the extension the Kaplan-Meier estimator of the distribution function for the first event time and the Inverse Probability of Censoring Weights for the second time (Lin DY, Sun W, Ying Z (1999) <doi:10.1093/biomet/86.1.59> and (ii) another estimator based on Kaplan-Meier weights (Una-Alvarez J, Meira-Machado L (2008) <https://w3.math.uminho.pt/~lmachado/Biometria_conference.pdf>). The proposed methods are the landmark estimators based on subsampling approach, and the estimator based on weighted cumulative hazard estimator. The package also provides nonparametric estimator conditional to a given continuous covariate. All these methods have been submitted to be published.

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2.70 score 5 scripts 140 downloads

presmoothedTP - Presmoothed Landmark Aalen-Johansen Estimator of Transition Probabilities for Complex Multi-State Models

Multi-state models are essential tools in longitudinal data analysis. One primary goal of these models is the estimation of transition probabilities, a critical metric for predicting clinical prognosis across various stages of diseases or medical conditions. Traditionally, inference in multi-state models relies on the Aalen-Johansen (AJ) estimator which is consistent under the Markov assumption. However, in many practical applications, the Markovian nature of the process is often not guaranteed, limiting the applicability of the AJ estimator in more complex scenarios. This package extends the landmark Aalen-Johansen estimator (Putter, H, Spitoni, C (2018) <doi:10.1177/0962280216674497>) incorporating presmoothing techniques described by Soutinho, Meira-Machado and Oliveira (2020) <doi:10.1080/03610918.2020.1762895>, offering a robust alternative for estimating transition probabilities in non-Markovian multi-state models with multiple states and potential reversible transitions.

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1.70 score 171 downloads

presmTP - Methods for Transition Probabilities

Provides a function for estimating the transition probabilities in an illness-death model. The transition probabilities can be estimated from the unsmoothed landmark estimators developed by de Una-Alvarez and Meira-Machado (2015) <doi:10.1111/biom.12288>. Presmoothed estimates can also be obtained through the use of a parametric family of binary regression curves, such as logit, probit or cauchit. The additive logistic regression model and nonparametric regression are also alternatives which have been implemented. The idea behind the presmoothed landmark estimators is to use the presmoothing techniques developed by Cao et al. (2005) <doi:10.1007/s00180-007-0076-6> in the landmark estimation of the transition probabilities.

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1.70 score 1 stars 189 downloads

p3state.msm - Analyzing Survival Data from an Illness-Death Model

Contains functions for data preparation, prediction of transition probabilities, estimating semi-parametric regression models and for implementing nonparametric estimators for other quantities. See Meira-Machado and Roca-Pardiñas (2011) <doi:10.18637/jss.v038.i03>.

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1.00 score 1 stars 6 scripts 574 downloads